KMID : 1123920120260060894
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Korean Journal of Oriental Physiology and Pathology 2012 Volume.26 No. 6 p.894 ~ p.901
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Effect of Sopung-tang and tDCS on Motor function Recovery and GDNF Expression in Photothrombotic Brain Infarction Induced Rat Model
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Sim Ki-Cheol
Kim Gi-Do Kim Kyung-Yoon Jeong Hyun-Woo Kim Gye-Yeop
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Abstract
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he effect of Sopung-tang(SPT) and trans-cranial direct current stimulation(tDCS) was investigated in photothrombotic brain infarction(PTI) rats. Sprague-Dawley 80 rats, were divided into four groups. group ¥° was experiental control group(n=20), group ¥± was PTI induced and oral administration of SPT(n=20), group ¥² was PTI induced and tDCS administration(n=20) and group ¥³ was PTI induced and SPT and tDCS administration for 28 days on stroke rats(n=20). Analysis the neurological function test, 25 point behavior functional score test, and immunohistochemistric finding of GDNF expression, and electron microscopy assessment In motor behavior test, the outcome of group ¥³ was significantly difference than the other group, and In immunohistochemistric finding, group ¥±, ¥², ¥³ were increase GDNF expression on 28 days, In electron microscopy finding, the all groups were degenerated of cell organelles, and synaptic plasticity were improvement of group ¥±, ¥², ¥³(especially group ¥³) These results suggest that, 28days application of SPT and tDCS was the motor function and histopathologic, micro-morphological improvement of motor function recovery and positive influence on synaptic plasticity
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KEYWORD
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photothrombotic brain infarction, Sopung-tang, tDCS, GDNF
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